Research

Presentations & Publications

The physicians of Retina Group of Sarasota are nationally and internationally renowned for their contributions to the advancement of retinal science and medicine. See below for a list of their publications and presentations.

  • 1981 Wong KL, Ai E, Jones JV, & Young D: Visual loss as the initial symptom of systemic lupus erythematosus. Am J Ophthalmol 92:238

  • 1983 Wong KL & Howes EL Jr.: Intraocular injection of prostaglandins: Modification of response to circulating bacterial endotoxin. Arch Pathology 101:275 (1983).

  • 1984 Rosenbaum JT, Wong KL, Perez JD, Raymond W, Howes EL Jr.: Characterization of endotoxin-induced C5-derived chemotactic activity in aqueous humor. Invest Ophthalmol Vis Sci. 25:1184 (1984).

  • 1985 Howes EL Jr., Wong KL, Hartiala KT, Webster RO, Rosenbaum JT: Complement and polymorphonuclear leukocytes do not determine the vascular permeability induced by intraocular LPS. Am J Path 118:35 (1985).

  • 1988 Ai E., Wong KL: Ophthalmic manifestations of AIDS. Ophthalmol Clin of North Amer. 1:53 (1988).

  • 1999 Olk RJ, Fribert TR, Stickney KL, Akduman L, Wong KL, Chen MC, Levy MH, Garcia CA, Morse LS: Therapeutic Benefits of Infrared (810 nm) Diode Laser Macular Grid Photocoagulation in Prophylactic Treatment of Nonexudative Age-Related Macular Degeneration: Two-year Results of a Randomized Pilot Study. Ophthalmology 106: 2082.(1999).

  • 2001 Wong KL, Grabow HB: Simplified Technique to Remove Posteriorly Dislocated Lens Implants. Archives of Ophthalmology. 119:273 (2001).

  • 2006 Friberg TR, Musch DC, Lim JI, Morse L, Freeman W, Sinclair S, PTAMD Study Group: Prophylactic Treatment of Age-Related Macular Degeneration Report Number 1: 810—Nanometer Laser to Eyes with Drusen. Unilaterally Elilgible Patients. Ophthalmology 113:612 (2006).

  • Hudson HL, Land SS, Heir JS, Stulting RD, Singerman L, Lichter PR, Sternberg P, Chang DF, IMT-002 Study Grouop: Implantable Miniature Telescope for the Treatment of Visual Acuity Loss Resulting from End-Stage Age-Related Macular Degeneration: 1-year Results. Ophthalmology 113:1987 (2006).

  • PKC-DRS 2 Group. Effect of Ruboxistaurin on Visual Loss in Patients with Diabetic Retinopathy. Ophthalmology 113:2221 (2006).

  • 2007 Diabetic Retinopathy Clinical Research Network: Diurnal Variation in Retinal Thickening Measurement by Optical Coherence Tomography in Center Involved Diabetic Macular Edema. Arch Ophthalmol 124:1701 (2007).

  • Diabetic Retinopathy Clinical Research Network: Relationship Between Optical Coherence Tomography-Measured Central Retinal Thickness and Visual Acuity in Diabetic Macular Edema. Ophthalmology 114:525 (2007).

  • Dexamethasone DDS Phase II Study Group: Randomized Controlled Study of an Intravitreous Dexamethasone Drug Delivery System in Patients with Persistent Macular Edema. Arch Ophthalmol 125:309 (2007).

  • 2009 The SCORE Study Research Group: A Randomized Trial Comparing the Efficacy and Safety of Intravitreal Triamcinolone with Observation to Treat Vision Loss Associated with Macular Edema Secondary to Central Retinal Vein Occlusion. The Standard Card vs. Corticosteroid for Retinal Vein Occlusion (SCORE) Study Report 5. Arch Ophthalmol 127:1101 (2009).

  • The SCORE Study Research Group: A Randomized Trial Comparing the Efficacy and Safety of Intravitreal Triamcinolone with Standard Care to Treat Vision Loss Associated with Macular Edema Secondary to Branch Retinal Vein Occlusion. The Standard Card vs. Corticosteroid for Retinal Vein Occlusion (SCORE) Study Report 6. Arch Ophthalmol 127:1115 (2009).

  • Wong, Keye L. “Surgery for Submacular Hemorrhage” Retina and Vitreous Surgery. Ed. Abdhish Bhavsar. Page 125-132. Elsevier Health Sciences. 2009.

  • 2010 Wong, Keye. “Defining Diabetic Retinopathy Severity” in Diabetic Retinopathy: Evidence-Based Management. Ed. David J. Browning. Pages 105-120. Springer 2010.

  • Wong, Keye. “Diagnostic Techniques in Clinical Practice – OCT, FA, Ultrasound.” In Diabetic Retinopathy: Evidence-Based Mangement. Ed David J Browning. Pages 121-139. Springer 2010.

  • 2012 Wong, Keye. “Anti-VEGF Treatment of Diabetic Retinopathy” in Current Drug Therapy Ed. Michael Stewart. 7:96-100 (2012).

  • 2020 Mansour SE, Browning DJ, Wong K et al. The Evolving Treatment of Diabetic Retinopathy. Clin Ophthalmol. 14:653-678 (2020).

  • 2020 Niffenegger JH, Fong DS, Wong KL et al. Treatment of Secondary Full Thickness Macular Holes with Topical Therapy. Ophthalmology Retina. 4:695-699 (2020).

  • Niffenegger JH, Fong DS, Wong KL, and Modjtahedi BS. Treatment of secondary full-thickness macular holes with topical therapy. Ophthalmology Retina. In Press, doi.org/10.1016/j.oret.2020.01.014
  • Niffenegger JH, Soltero A, Niffenegger JS, Yang S, and Adamus G. Prevalence of Hepatocyte Growth Factor and Autoantibodies to α-HGF as a New Etiology for Bilateral Diffuse Uveal Melanocytic Proliferation Masquerading as Neovascular Age-Related Macular Degeneration. J Clin Exp Ophthalmol 2018: 9(4): doi:10.4172/2155-9570.1000740.
  • Aiello LP, Ayala AR, Antoszyk AN, Arnold-Bush B, et al. Diabetic Retinopathy Clinical Research Network. Assessing the effect of personalized diabetes risk assessments during ophthalmologic visits on glycemic control: A randomized clinical trial. JAMA Ophthalmol. 2015 Aug;133(8):888-96
  • Scott IU, Oden NL, VanVeldhuisen PC, Ip M, et al. SCORE Study Investigator Group SCORE Study Report 7: Incidence of intravitreal silicone oil droplets associated with staked-on vs luer cone syringe design. Am J Ophthalmol. 2009 Nov;148(5):725-732
  • Ahmed M, Niffenegger JH, Jakobiec FA, Ben-Arie-Weintrob Y, Gion N, Androudi S, Folberg R, Raizman MB, Margo CE, Smith ME, McLean IW, Caya JG, Foster CS. Diagnosis of limited ophthalmic Wegener granulomatosis: distinctive pathologic features with ANCA test confirmation. International Ophthalmology June 23 2007 ePub
  • Diabetic Retinopathy Clinical Research Network., Fong DS, Strauber SF, Aiello LP, et al. Comparison of the modified Early Treatment Diabetic Retinopathy Study and mild macular grid laser photocoagulation strategies for diabetic macular edema. Arch Ophthalmol. 2007 Apr;125(4):469-80
  • Diabetic Retinopathy Clinical Research Network., Danis RP, Glassman AR, Aiello LP, et al. Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema. Arch Ophthalmol. 2006 Dec;124(12):1701-7
  • Choroidal Neovascularization Prevention Trial Research Group. Laser treatment in fellow eyes with large drusen: updated findings from a pilot randomized clinical trial. Ophthalmology. 2003 May;110(5):971-8
  • Melia BM, Abramson DH, Albert DM, et al. Collaborative Ocular Melanoma Study Group..Collaborative ocular melanoma study (COMS) randomized trial of I-125 brachytherapy for medium choroidal melanoma. I. Visual acuity after 3 years COMS report no. 16. Ophthalmology. 2001 Feb;108(2):348-66
  • Phelps DL, Linblad A, Breadford JD, et al. Supplemental Therapeutic Oxygen for Prethreshold Retinopathy Of Prematurity (STOP-ROP), a randomized, controlled trial. I: primary outcomesSTOP-ROP Multicenter Study GroupPediatrics200010529531010. Pediatrics. 2000;105(2):295-310
  • Albert DM, Diener-West M, Robinson NL et al. Histopathologic characteristics of uveal melanomas in eyes enucleated from the Collaborative Ocular Melanoma Study. COMS report no. 6 Am J Ophthalmol 1998 May; 125(6):745-766.
  • Hawkins BS, Vine AK, Willis J, et al. The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre- enucleation radiation of large choroidal melanoma I: Characteristics of patients enrolled and not enrolled COMS report no. 9 Am J Ophthalmol 1998 May; 125(6):767-778
    -Niffenegger JH, Topping TM, Mukai S. Stickler's Syndrome. International Ophthalmology Clinics 33:271-280, 1993
  • Niffenegger J. Book Review: Ophthalmology: What Shall I Do? By Jack Kanski and Bev Daily. JAMA Ophthalmology. 1992;110(2):179
  • Niffenegger JH, Jakobiec FA, Shore JW, Albert DM. Adult extrarenal rhabdoid tumor of the lacrimal gland. Ophthalmology 99:567-74, 1992
  • Seiving PA, Niffenegger JH, Berson EL. Electrophysiologic findings in selected pedigrees with choroideremia. American Journal of Ophthalmology 101:361-367, 1986
  • Benson DW, Weinstein ES,Niffenegger JH, Yokum M, Fry DE. Subpopulations of skeletal muscle mitochondria: response to ischemia. American Surgeon 51:682-686, 1985. Second Place winner, Forum of Progress in Surgery, 53rd. Assembly of the Southeastern Surgical Conference, 1985

Publications:

  • Conklin BS. Richter ER. Kreutziger KL. Zhong DS. Chen C. Development and evaluation of a novel decellularized vascular xenograft. Medical Engineering and Physics. 24:173-83, 2002.

  • Singh N. Amin S. Richter E. Rashid S. Scoglietti V. Jani PD. Wang J. Kaur R. Ambati J. Dong Z. Ambati BK. Flt-1 intraceptors inhibit hypoxia-induced VEGF expression
    in vitro and corneal neovascularization in vivo. Investigative Ophthalmology & Visual Science.
    46(5):1647-52, 2005.

  • Ambati BK. Nozaki M. Singh N. Takeda A. Jani PD. Suthar T. Albuquerque RJ. Richter
    E    . Sakurai E. Newcomb MT. Kleinman ME. Caldwell RB. Lin Q. Ogura Y. Orecchia A. Samuelson DA. Agnew DW. St Leger J. Green WR. Mahasreshti P. Curiel DT. Kwan D. Marsh H. Ikeda S. Leiper LJ. Collinson JM. Bogdanovich S. Khurana TS. Shibuya M. Baldwin ME. Ferrara N. Gerber H. De Falco S. Witta J. Baffi JZ. Raisler BJ. Ambati J. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 443: 993-997, 2006.

  • Singh N. Higgins, E. Amin S. Jani P. Richter E. Patel A. Kaur R. Wang J. Ambati J. Dong Z. Ambati BK. Unique homologous siRNA blocks hypoxia-induced VEGF upregulation
    in human corneal cells and inhibits and regresses murine corneal neovascularization. Cornea. 26(1):65-72, 2007.

  • Zheng M, Fields MA, Liu Y, Cathcart HM, Richter E, Atherton SS. Neutrophils protect the retina of the injected eye from infection after anterior chamber inoculation of HSV-1 in BALB/c mice. Invest Ophthalmol Vis Sci. 49(9):4018-4025, 2008.

  • Richter ER, Dias JK, Gilbert JE 2nd, Atherton SS. Distribution of herpes simplex virus type 1 and varicella zoster virus in ganglia of the human head and neck. J Infect Dis. 200(12):1901-6, 2009.

  • Faulks SW. Richter ER. Kylstra JA. New device to test potential visual acuity compared with gold standard Potential Acuity Meter in cataractous eyes. (Awarded 2011-2012 Helma Research Award for Best Research Project, Storm Eye Institute, Charleston, SC)

  • Richter ER, Guffey D, Trivedi R, Nutaitis MN. Comparison of clinic patient wait-time and appointment duration during a change in Electronic Health Record (EHR) systems. 2014

  • Itty S, Richter ER, McCannel TA. Choroidal melanoma in a patient with Waardenburg Syndrome. Retinal Cases & Brief Reports 9(4):327-9, Fall 2015.

  • Klufas MA, Richter E, Itty S, Moreno C, McCannel CA, McCannel TA. Comparison of Gene Expression Profiling and Chromosome 3 Analysis by Fluorescent in situ Hybridization and Multiplex Ligation Probe Amplification in Fine-Needle Aspiration Biopsy Specimens of Uveal Melanoma. Ocul Oncol Pathol. 4(1):16-20. Dec 2017.

  • Richter ER. Age Related Macular Degeneration: Challenges of the Baby Boom. New Retinal Physician, Volume: 18, Issue: Clinical Conversations in Retina: Highlights from a Virtual Conference page 8. June 2021.

Patent applications:

  • Richter ER. Kylstra JA. U.S. Patent Application 61/653,171.
    Devices, Systems, and Methods for Evaluation of the Eye. Filed May 30, 2012. (Handheld device for measuring potential visual acuity using an indirect ophthalmoscope, 20 diopter lens, and transparent calibrated ETDRS eyechart).

Presentations/Lectures at National/Regional Meetings:

  • Richter ER, Conklin BS. Optimization and Characterization of
    heparin coating of a novel decellularized vascular xenograft. Petit Institute for Bioengineering & Bioscience Educational Partners Symposium, Atlanta, Georgia, November 2000.

  • Richter ER. Atherton SS. Collection and extraction of DNA from formalin-fixed cadavers. International Herpesvirus Workshop, Seattle, Washington, July 2006.

  • Richter ER. Gilbert JE. Atherton SS. Collection and extraction
    of DNA from formalin-fixed cadavers to determine the prevalence and distribution of HSV-1 in human ganglia. MCG Neuroscience Symposium, Augusta, Georgia, January 2007.

  • Richter ER. Gilbert JE. Atherton SS. Presence of HSV-1 in ocularly-related
    ganglia in human cadavers. ARVO Annual Meeting, Fort Lauderdale, Florida, May 2007.

  • Zheng M. Fields MA. Liu Y. Richter E. Cathcart H. Atherton SS. Neutrophil-mediated virus spreading after HSV type 1 infection of the murine anterior chamber. ARVO, Fort Lauderdale, Florida, May 2007.

  • Richter ER. Gilbert JE. Atherton SS. Presence of herpes simplex virus type 1 in ganglia of human cadavers. Medical Scientist Training Program Annual MD/PhD Student Conference. Keystone, Colorado, July 2007.

  • Richter ER. Atherton SS. Determining the prevalence of HSV-1 in ganglia of the human head and neck. American Association of Anatomists- Experimental Biology Meeting. San Diego, California, April 2008.

  • Richter ER. Atherton SS. HSV-1, HSV-2, and VZV prevalence and correlation in ganglia of the head and neck of a large population of human cadavers. International Herpesvirus Workshop, Estoril, Portugal, July 2008.

  • Richter ER. A compromising situation: case report on pituitary adenoma. Pfizer Medical & Academic Program: Clinical Decisions in Neuroophthalmology, Charleston, South Carolina, December 2010.

  • Richter ER. Kylstra JA. Pipe dreams: a new way to measure potential visual acuity. Kiawah Eye Meeting, Kiawah, South Carolina, June 2012.

  • Richter ER. Waring GO. Biomechanical property changes in keratoconic eyes after collagen crosslinking using ORA software. ASCRS Annual Meeting, San Francisco, California, April 2013.

  • Richter ER. Kylstra JA. Preliminary assessment of a new device to test potential visual acuity when compared to gold standard PAM. ARVO Annual Meeting, Seattle, Washington, May 2013.

  • Richter ER. Kylstra JA. Comparison of SCALE and gold standard PAM in predicting post-cataract visual acuity. Kiawah Eye Meeting, Kiawah, South Carolina, May 2013.

-Richter ER. Nutaitis MN. Malignant glaucoma: case presentation
and treatment recommendations. North Carolina Society of Eye Physicians and Surgeons Annual Meeting, Asheville, North Carolina, September 2013.

  • Richter ER. Nutaitis MN. Surprise presentation of an interesting case. Charleston Ophthalmological Society, Charleston, South Carolina, September 2013.

  • Richter ER. Glare and potential acuity testing: a new perspective. ACES/SEE Caribbean Eye Meeting. Cancun, Mexico, January 2014.

  • Richter ER. Kylstra JA. Use of new device to help determine preferred retinal locus in patients with eccentric viewing. 11th International Conference on Low Vision. Melbourne, Australia, April 2014 (accepted).

  • Richter ER. Nutaitis MN. Use of femtosecond laser to aid in
    cataract surgery for anterior subcapsular cataract. ASCRS Meeting, Boston, Massachusetts, April 2014.

  • Faulks SW. Richter ER. Kylstra JA. New Device to Test Potential Visual Acuity Compared With Gold Standard Potential Acuity Meter in Cataractous and Normal Eyes. ASCRS Meeting, Boston, Massachusetts, April 2014. (Poster Winner)

  • Richter ER. Guffey D. Nutaitis MN. An Epic change: comparison of patient wait time and appointment duration with a change in EMR systems. Kiawah Eye Meeting, Kiawah Island, South Carolina, May 2014.

  • Richter ER. Kreiger AE. Optic Disc Drusen and Choroidal Neovascular Membranes. Jules Stein Eye Institute, Los Angeles, California, February 2015.

  • Richter ER. Itty S. McCannel TM. Choroidal Melanoma in a Patient with Waardenburg Syndrome. Pacific Retina Club. Los Angeles, California, March 2015.

  • Richter ER. Guffey D. Trivedi R. Nutaitis MN. Comparison of Clinic Patient Wait-Time and Appointment Duration During Change in Electronic Health Record Systems. ASCRS Annual Meeting, San Diego, California, April 2015. (Best Paper of Session Award)

  • Richter ER. Itty S. McCannel TA. Comparison of Gene Expression Profiling and Chromosome 3 Analysis by Fluorescent In Situ Hybridization in Fine Needle Aspiration Biopsy Specimens of Uveal Melanoma. ARVO Annual Meeting, Denver, Colorado, May 2015 (Communicator Award)

  • Klufas,MA. Itty S. Richter ER. McCannel CA. McCannel TA. Comparison of Gene Expression Profiling (GEP) with Chromosome 3 by FISH and GEP with MLPA in Fine Needle Aspiration Biopsy Specimens of Uveal Melanoma – UCLA Experience. Wills Oncology Conference, Philadelphia, Pennsylvania, May 2015.

  • Richter ER. Itty S. McCannel CA. Moreno C. McCannel TA. Comparison of Molecular Prognostic Test Results in Fine Needle Aspiration Biopsy of Uveal Melanoma. ASRS, Vienna, Austria, July 2015.

  • Richter ER. Candidemia Involvement in the Eye. Grand Rounds: Jules Stein Eye Institute, Los Angeles, California, March 2016.

  • Richter ER. OCT Staging of ERMs as a Prognostic Indicator for
    Surgical Results. Florida Society of Ophthalmology Masters in Ophthalmology Meeting, Miami, Florida, June 2017.

  • Richter ER. Clinical Conversations In Retina. Age-Related Macular Degeneration: The Baby Boom: Age Ain’t Nothing But A Number. Virtual Presentation, March 2021.